Prof. Alaa Eldin Ismail
MD-FICS • Cairo, Egypt

Prof. Alaa Eldin
Ismail

Professor of General Surgery & Chairman of Liver Surgery Dept, Ain Shams University.
Founder of the National Hepatology and Tropical Medicine Research Institute (NHTMRI).

Research & Trials Full Bio

Career Highlights

Professional Appointments

Academic Leadership

  • • Professor, Dept of General Surgery, Ain Shams University
  • • Chairman, Liver Surgery Dept, Ain Shams University
  • • Chairman, Scientific Board of Egyptian Fellowship of Surgery (MOHP)

Research Director

  • • Director, Liver Research Unit, Ain Shams
  • • Director, Stem Cell Research Division, Ain Shams
  • • Founding Director, NHTMRI (1996-2006)

Ethics & Advisory

  • • Chairman, Ethical Review Committee (Surgery Dept, Ain Shams)
  • • Member, Ethical Committees (VACSERA, GOTHI, Armed Forces College)
  • • Surgery Advisor, Egyptian Health Insurance Org.

Societies & NGOs

  • • Chairman, Egyptian Society for Healthcare Development (ESHD)
  • • Past Governor & President, American College of Surgeons (Egypt Chapter)
  • • Member, Supreme Council of Tudor Bilharz Institute

Policy & Planning

  • • Member, Drug Policies & Planning Center (MOHP)
  • • Member, Central Admin of Pharmaceutical Affairs (CAPA)
  • • Member, Academy of Scientific Research Specialized Council

Academic Chronology

10/2005 - Present

Chairman of Liver Surgery Dept

Faculty of Medicine, Ain Shams University

4/1992 - Present

Professor of General Surgery

Faculty of Medicine, Ain Shams University

4/1987 - 3/1992

Associate Professor

Ain Shams University

4/1982 - 3/1987

Lecturer of General Surgery

Ain Shams University

3/1974 - 3/1982

Resident & Clinical Demonstrator

Ain Shams University

Education

MD Surgery (1981) MSc Surgery (1979) BSc Medicine (1972)

Investigator Profile

Research & Clinical Trials

Principal Investigator Roles

Hepatitis C & Liver Cancer (USA Collaboration)

Georgetown University & University of Maryland Studies:

  • Malignant Complications of Chronic HCV
  • HCV Infection and Risk of Liver Cancer and Non-Hodgkins Lymphoma in Egypt
  • HCV Genomic Sequence Variation in Chronic Liver Disease and HCC

Stem Cell Research

NHTMRI & Ain Shams Studies:

  • Umbilical cord stem cells as a source of hepatic progenitor cells
  • Bone marrow stem cell as a source of cells for liver regeneration
  • Intra-splenic Sonar guided Bone-Marrow Stem Cell Transplantation

ANRS (France) Clinical Trials

  • Efficacy of pegylated interferon (PEG-IFNα-2a) alone in acute HCV (ANRS 1213)
  • Combination PEG-IFNα-2a plus ribavirin in untreated chronic HCV (ANRS 1211)
  • Survey on acute hepatitis in Fever Hospitals (Greater Cairo)

Endemic & Surgical Studies

  • Prevalence of Chronic Hepatitis B and Lamivudine safety
  • Transplantation of living liver graft in different possible sites
  • Feasibility for non-Invasive screening for HCV related fibrosis

International Fellowships

Japan

Tokyo, Japan (1996)

Tokyo International Medical Center & Tokyo Univ.

USA

Memphis, USA (1994)

Research Fellow

France

Paris, France (1989-1990)

Paul Brousse Hospital

KSA

Saudi Arabia (1983-1984)

Consultant Surgery

Core Focus Areas

  • HCC Research (Surgical Resection)
  • Stem Cell Applications in Liver
  • Tropical Surgery
  • Endemic Disease Control
  • ATLS Training
Institutional Legacy

National Hepatology & Tropical Medicine Research Institute (NHTMRI)

Prof. Alaa established the NHTMRI (1996-2006) as a center of excellence at the MOHP. The facility is dedicated to the diagnosis, treatment, and prevention of liver diseases in Egypt and serves as a training hub for doctors across the Middle East and Africa.

Key Achievements:

  • • Development of Tropical Surgery Unit.
  • • Programs for disease control in New Valley & Sinai.
  • • Established labs for Schistosoma life cycle simulation.

International Collaborations

🇺🇸 United States

University of Maryland, Georgetown, NIH, Johns Hopkins, University of Texas, University of Georgia.

🇪🇺 Europe

France (Pasteur Inst, Val De Gras, ANRS), Sweden (Lund Univ), Germany (Univ of Tuebingen), UK (Leeds), Finland (Kuopio).

🇪🇬 Egypt

Cairo Univ, Ain Shams, Assiut, Minia, AUC, National Liver Institute, National Cancer Institute.

Academic Output

Scientific Contributions

Selected Publications

Partial Archive

Stem Cell Therapy Improves the outcome of Liver Resection in Cirrhotics

Alaa Ismail, Osama Fouad, M.Andaleeb (Accepted in Nature Journal Jan.2008)

Clinical significance of aflatoxin, mutant P53 gene and sIL-2 receptor in liver cirrhosis and hepatocellular carcinoma

J Egypt Soc Parasitol. 2006 Apr; 36(1):221-39

P53 mutations in hepatocellular carcinoma patients in Egypt

Int J Hygiene Environ Health 2005; 208:263-70

The role of the Tumour Necrosis Factor (TNF)-FasL and HCV in the development of Hepatocellular Carcinoma

Journal of Clinical Virology 2005. Oct; 34(2):140-6

Cellular immune responses in seronegative sexual contacts of acute hepatitis C patients

J Virol. 2004 Nov; 78(22):12252-8

Pegylated interferon alpha therapy in acute hepatitis C: relation to hepatitis C virus-specific T cell response kinetics

Hepatology. 2004 Jun; 39(6):1721-31

Can hyaluronic acid be a predictive marker in complicated liver disease as spontaneous bacterial peritonitis and hepatocellular carcinoma?

Kasr El-Aini medical journal; 2005: vol 11, No 5, 327-333

Clinical and immunological results of segmental splenectomy in schistosomiasis

British Journal of Surgery, July 1986

Hepatectomy for primary Hepatocellular cancer

The Egyptian Journal of Surgery, April 1983

A pilot study on haematological changes following segmental splenectomy

The Egyptian Journal of Surgery, August 1982

...and 30+ more publications covering 1982-2008

Academic Supervision

PhD & MSc Theses

Doctoral (PhD) Supervision

Stem cell and chronic liver disease (2008)

Role of bone marrow stem cell in improving the outcome of liver resection in cirrhotic (2008)

LDLT in Egypt: Preliminary results (2004)

Pancreatic Islet cell transplantation in patients diabetics (Joined supervision with USA, 1992)

Role of R.F. ablation in management of deep HCC and liver metastasis (2005)

Masters (MSc) Supervision

Intestinal Transplantation (2007)

Reversal of Hepatic fibrosis (2001)

Laparoscopic era and its effect on cholecystectomy (1998)

Cancer Breast with pregnancy (1992)

...supervised over 40+ theses

Practical Workshops Organized

Infectious Disease Research Training Hepatitis C Workshop (MOHP/Nasser Inst) Research Ethics (NIH Fogarty) Manuscript Writing Grant Writing (Georgetown) Good Laboratory Practice Clinical Trials (FDA)